Objective

Know when/why/how to search primary literature databases

Subdomains

Medline, Embase, CINAHL via Ovid, Pubmed;  including Boolean operations, wildcards;  Google Scholar

Resources

Pubmed tutorial

OvidSP Medline Tutorial

Ovid Quick Reference Card - boolean & truncation tricks

Google Scholar - about, tips

  Fundamentals

Objective

Know when/why/how to search Cochrane & specialized sites/databases databases

Subdomains

CDSR, CCCTR

Resources

Cochrane Library Help

www.theheart.org

Objective

Finding unpublished results

Subdomains

Finding trials in progress, conference proceedings, discussions

Resources

Current Controlled Trials

IFPMA Clinical Trials Portal

Clinical Study Results.org

ClinicalTrials.gov

EudraCT

Stroke Trials [similar directories exist for many diseases... search Google]

FDA Center for Drug Evaluation & Research

Objective

Finding other peoples’ critiques/evaluations

Subdomains

NICE, CEDAC/CADTH, journalwatch, ACP Journal Club, EBM, Bandolier, TherInit

Resources

Therapeutics Initiative   ACP Journal Club   CADTH   EBM Online

Bandolier    NICE

Objective

Guidelines:  sources, databases

Subdomains

Resources

www.guidelines.gov      BC MoH CPGs     UK Guidelines Finder

AHA Guidelines     NICE Guidelines    Agency for Healthcare Research & Quality

Objective

Formulating an answerable Focused Clinical Question

Subdomains

PICO format

Resources

How to Form an Answerable Clinical Question.pdf

PICO Question Worksheet.pdf

Objective

Retrieving fulltext online

Subdomains

Ovid, UBC RSVPN, ILL, CISTI

Resources

UBC RSVPN login

CISTI

Objective

Building an eDocs collection / organizing literature

Subdomains

Resources

Objective

Common statistical representations (descriptive and inferential)

Subdomains

what's a p-value? what's an OR, RR, ARR, RRR, HR, NNT/H? power, clinical vs. statistical significance, confidence intervals, kaplan meier plots, forest plots

Resources

Evidence-Based Pharmacotherapy Module-Ploewen.pdf

How to read a paper-Statistics for the non-statistician 1-Different types of data need different statistical tests-BMJ.pdf

How to read a paper-Statistics for the non-statistician 2-Significant relations and their pitfalls-BMJ.pdf

Biostatistics for the Clinician PSAP-4th Ed.pdf

The number needed to treat turns 20 — and continues to be used and misused-CMAJ.pdf

Toward Evidence-Based Medical Statistics-1- The P Value Fallacy-AIM.pdf

To P or Not to P- Why Use a P Value Anyway-MS.pdf

ACP Primer on 95% confidence intervals.pdf

Survival probabilities (the Kaplan-Meier method)-BMJ.pdf

Forest plots-trying to see the wood and the trees-BMJ.pdf

Statistics Notes- The odds ratio-BMJ.pdf

Objective

Critical Appraisal/Design of: Guidelines

Subdomains

Resources

AGREE instrument for assessing practice guidelines-agreecollaboration.org

COGS-Standardized Reporting of Clinical Practice Guidelines-Proposal from the Conference on Guideline Standardization-AIM.pdf

Guidance for Guidelines-NEJM.pdf

Practice guidelines developed by specialty societies- the need for a critical appraisal.pdf

Practice

AHA-ASA 2007 Guidelines for the Early Management of Adults  With Ischemic Stroke.pdf

Diagnosis and Management of Stable Chronic Obstructive Pulmonary Disease-ACP 2007 Guidelines.pdf

CHEP 2007 Clinical Summary.pdf

Guidelines for anticoagulant use in acute coronary syndromes-critique-Lancet.pdf

QuickSearch in Pubmed for more Guidelines

Objective

Critical Appraisal/Design of: simple RCTs

Subdomains

CONSORT, ITT analysis, understanding/evaluating composite endpoints

Resources

How to Use an Article About Therapy or Prevention-JAMA

CONSORT statement for RCT reporting

CASP RCT Appraisal Tool.pdf

How to read a paper-Papers that report drug trials-BMJ.pdf

Intention-to-treat principle-CMAJ.pdf

What is meant by intention to treat analysis-Survey of published RCTs-BMJ.pdf

Validity of composite end points in clinical trials-BMJ.pdf

Composite Clinical Endpoints: Proceed With Caution

Cautionary tales in the clinical Interpretation of therapeutic trial reports-IMJ.pdf

Practice

WHS-RCT of Low-Dose Aspirin in the Primary Prevention of CV disease in Women-NEJM.pdf

RCT Comparing tinzaparin and dalteparin for the Outpatient Treatment of DVT-PE-ArchIM.pdf

RCT of effects of Hpylori infection and its eradication on heartburn and GERD- Bristol helicobacter project-BMJ.pdf

QuickSearch in Pubmed for more RCTs

Objective

Application of clinical trial (RCT) quality scoring systems

Subdomains

Jadad

Resources

Measuring quality of trials Editorial-JAMA.pdf

How to read a paper-Assessing the methodological quality of published papers-BMJ.pdf

Jadad Score

Objective

Criteria for how/when to apply study results to my patient/practice/decision

Subdomains

Resources

How to Decide on the Applicability of Clinical Trials Results to Your Patient-JAMA

Treating Individuals-External validity of randomised controlled trials-Lancet.pdf

Integrating Research Evidence with the Care of the Individual Patient-JAMA

Objective

Principles of Evidence-Based Practice

Subdomains

Resources

Evidence-Based Pharmacotherapy Module-Ploewen.pdf

Oxford CEBM Levels of Evidence.pdf

Grades of Recommendations-Guyatt 2001.pdf

Method for Grading Health Care Recommendations-JAMA

Scientific Evidence and Medical Practice-The Drunkard's Walk-ArchIM.pdf

Objective

Know the functions of and resources available at health policy / analysis organizations

Subdomains

NPDUIS, IMS, CADTH

Resources

NPDUIS

IMS Health Canada

CADTH