Table of Contents

THERAPEUTIC DRUG CONCENTRATION RANGES

DRUG THERAPEUTIC RANGE WHEN TO SAMPLE
Carbamazepine 20-50 umol/L Trough
Cyclosporine (Radioimmunoassay)
SOT: 100-450mcg/L
BMT: 200-400mcg/L		 Trough
CIVI: 24 hours post-dosage change 
Digoxin A. fib: 1.0-2.5 nmol/L
CHF: 0.6-1 nmol/L		 Trough (minimum 6 hours post dose)
Ethosuximide 300-700 umol/L Trough
Lithium 0.5-1.5 mmol/L Trough (12 hours post dose)
Phenobarbital 60-160 umol/L Trough
Phenytoin 40-80 umol/L (20-40 umol/L acceptable) Trough
IV: 2-4 hours post load
Free phenytoin 4-8 umol/L Trough
Primidone 25-50 umol/L Trough (Note: Primidone is metabolized to phenobarb)
Procainamide 20-40 umol/L Trough
n-acetyl-procainamide 10-30 umol/L Trough
NAPA + Procainamide TOXIC: >100 umol/L Trough
Quinidine 7-15 umol/L Trough
Tacrolimus SOT: 5-15 mcg/L
BMT: 5-15 mcg/L		 Trough
CIVI: 24 hours post-dosage change
Theophylline 55-110 umol/L (28-55 umol/L also acceptable) Trough
CIVI: 18-24 h post-dosage change
Valproic Acid 350-700 umol/L Trough

Therapeutic range indicates desired drug concentrations. Interpretation of reported patient drug concentrations must take into account the duration and time of drug administration and the timing of the serum sample obtained for drug concentration determination.