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Table of Contents
COMPARISON OF SYSTEMIC CORTICOSTEROIDS
| Drug |
Equivalent
Pharmacologic Dose (mg) |
Mineralo-Corticoid
Potency1 |
Biological Half-Life
(hrs) |
HPA Axis Suppression
(mg)2 |
| Hydrocortisone (Solu-Cortef® ) |
20 |
2+ |
8-12 |
20-30 |
| Cortisone |
25 |
2+ |
8-12 |
25-35 |
Prednisone
(Deltasone® ) |
5 |
1+ |
24-36 |
7.5 |
| Methylprednisolone (Solu-Medrol®) |
4 |
0-0.5+ |
24-36 |
7.5 |
| Dexamethasone (Decadron®) |
0.75 |
0 |
36-54 |
1-1.5 |
1Mineralocorticoid effects are dose related; at
doses close to or within the basal physiologic range for glucocorticoid
activity, no such effect may be detectable.
2Daily dose that usually leads to
Hypothalamic-Pituitary-Adrenal (HPA) suppression
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