Table of Contents

COMPARISON OF SYSTEMIC CORTICOSTEROIDS

Drug Equivalent Pharmacologic Dose (mg) Mineralo-Corticoid Potency1 Biological Half-Life (hrs) HPA Axis Suppression (mg)2
Hydrocortisone (Solu-Cortef® ) 20 2+ 8-12 20-30
Cortisone 25 2+ 8-12 25-35
Prednisone
(Deltasone® )
5 1+ 24-36 7.5
Methylprednisolone (Solu-Medrol®) 4 0-0.5+ 24-36 7.5
Dexamethasone (Decadron®) 0.75 0 36-54 1-1.5

1Mineralocorticoid effects are dose related; at doses close to or within the basal physiologic range for glucocorticoid activity, no such effect may be detectable.

2Daily dose that usually leads to Hypothalamic-Pituitary-Adrenal (HPA) suppression