| Drug |
Dalteparin
(Fragmin®) |
Enoxaparin
(Lovenox®) |
Fondaparinux (Arixtra®) |
| Indications & Dose |
|
|
|
|
Prophylaxis of DVT/PE
- Major Orthopedic Trauma or Spinal Cord Injury
- General Surgery, Medicine, Total Knee
Arthroplasty, Elective Orthopedic Surgery
|
5000 units SC daily
2500-5000 units SC daily |
30mg SC Q12H
20-40mg SC daily1 |
2.5 mg SC daily1
2.5 mg SC daily1
|
Treatment of DVT/PE
|
200 units/kg SC daily (Max2=18,000units/day) |
1mg/kg SC Q12H1 (Max2=100mg
Q12H) OR 1.5mg/kg SC daily1 (Max2=180mg/day) |
5-10 mg SC daily1 (dependent on
weight) |
Acute Coronary Syndrome (ACS)
|
120 units/kg Q12H SC
(Max2=10,000 units Q12H) |
1mg/kg SC Q12H (Max2=100mg SC
Q12H) |
2.5 mg SC daily3 |
| Peak Onset (SC) |
4 hours |
3 hours |
2 hours |
Plasma Half-Life
(anti-Xa activity) |
119-139 minutes |
3.5-4.2 hours |
17-21 hours |
| Elimination |
renal |
renal |
renal |
| When to Hold SC Dose Prior to Surgery4 |
24 hours |
12 hours (or 24 hours with once daily dosing) |
24 hours |