Table of Contents

COMPARISON OF FORMULARY LOW MOLECULAR WEIGHT HEPARINS

Drug Dalteparin  (Fragmin®) Enoxaparin  (Lovenox®)
Indications & Dose    

Prophylaxis of DVT/PE

  • Major Orthopedic Trauma or Spinal Cord Injury
5000 units SC daily 30mg SC q12h
  • General Surgery,   Medicine, Total Knee Arthroplasty, Elective Orthopedic Surgery
2500-5000 units SC daily 20-40mg SC daily1

Treatment of DVT/PE

200 units/kg SC daily (Max2=18,000units/day) 1mg/kg SC q12h1 (Max2=100mgq12h) OR 1.5mg/kg SC daily1 (Max2=180mg/day)

Acute Coronary Syndrome (ACS)

120 units/kg q12h SC
(Max2=10,000 units q12h)
1mg/kg SC q12h (Max2=100mg SC q12h)
Peak Onset (SC) 4 hours 3 hours
Plasma Half-Life
(anti-Xa activity)
119-139 minutes 3.46-4.18 hours
Elimination renal renal
When to Hold SC Dose Prior to Surgery 24 hours 12 hours (or 24 hours with once daily dosing)

1 non-formulary indication at Vancouver Acute
2 the manufacturer recommends a maximum dose; however, dosage should be individualized and higher dosages may be administered