|
Indication |
Target INR |
Duration of Therapy |
Low intensity therapy
Prophylaxis of hip surgery |
1.6-2.3 |
Until patient is ambulatory and/or up to 4-6 weeks |
|
Moderate intensity therapy |
Treatment of DVT or PE
|
|
|
-
Due to reversible risk factors
|
2.0-3.0 |
3 months |
|
|
2.0-3.0 |
6-12 months (may consider indefinite) |
|
|
2.0-3.0 |
Indefinite |
|
Cardioverson for atrial fibrillation |
2.0-3.0 |
3
weeks prior and 4 weeks post cardioversion |
|
Chronic atrial fibrillation |
2.0-3.0 |
Indefinite |
|
Tissue heart valves |
2.0-3.0 |
3
months post surgery |
|
Mechanical aortic valve1 (normal left atrial size and normal
sinus rhythm) |
2.0-3.0 |
Indefinite |
| Acute
anterior myocardial infarction (MI) |
2.0-3.0 |
3
months post MI (with ASA 81mg daily)2 |
|
High intensity therapy |
|
|
|
Mechanical mitral valve1 (or aortic valve with atrial
fibrillation) |
2.5-3.5 |
Indefinite |
| 1St
Jude Medical bileaflet valve, Carbomedics bileaflet valve,
Medtronic-Hall tilting disc valve
2long-term use recommended
if meticulous INR monitoring is standard; target INR range 2.5-3.5
without concomitant aspirin or 2.0-3.0 with aspirin |