Table of Contents

DOSAGE EQUIVALENCE OF HMG CoA REDUCTASE INHIBITORS (“STATINS”)

 

Drug

 

Approximate Equivalent Dose3

 

Lovastatin (Mevacor®)

 

20 mg

 

Pravastatin (Pravachol®)

 

20 mg

 

Simvastatin1 (Zocor®)

 

10 mg (maximum 40 mg/dose)

 

Atorvastatin2 (Lipitor®)

 

5 mg

 

Fluvastatin (Lescol®)

 

40 mg

                                                          

Rosuvastatin (Crestor®)

 

2.5 mg 

1 formulary drug
2 atorvastatin 80 mg is formulary
3 dose equivalence based on a 25-30% reduction in LDL cholesterol

 

TARGET GOALS FOR CHOLESTEROL LOWERING

 

Level of Risk

 

Initiate Treatment if:

 

Target LDL (mmol/L)

 

High
(CAD, PVD, atherosclerosis, or  diabetes)

FRS 10yr risk of CV disease: ³ 20%

 

Consider treatment in all patients

 

< 2.0  OR
³ 50% ¯ baseline LDL

 

 

Moderate
FRS 10yr risk:  10-19%

 

LDL > 3.5 mmol/L
OR

TC/HDL >5.0
OR

hs-CRP > 2 mg/L
(test in men > 50 yrs, women > 60 yrs if LDL <3.5)

 

< 2.0  OR
³ 50% ¯ baseline LDL

 

Low
FRS 10yr risk: < 10%

 

LDL ³ 5.0 mmol/L

 

³ 50% ¯ baseline LDL

CAD=coronary artery disease;
PVD = peripheral vascular disease;
CV = cardiovascular;
FRS = Framingham Risk Score;
TC = Total cholesterol