Table of Contents

DOSAGE EQUIVALENCE OF HMG CoA REDUCTASE INHIBITORS (“STATINS”)

 

Drug

 

Approximate Equivalent Dose3

 

Lovastatin (Mevacor®)

 

20 mg

 

Pravastatin (Pravachol®)

 

20 mg

 

Simvastatin1 (Zocor®)

 

10 mg (maximum 40 mg/dose)

 

Atorvastatin2 (Lipitor®)

 

5 mg

 

Fluvastatin (Lescol®)

 

40 mg

                                                          

Rosuvastatin (Crestor®)

 

2.5 mg 

1 formulary drug
2 atorvastatin 80 mg is formulary
3 dose equivalence based on a 25-30% reduction in LDL cholesterol

TARGET GOALS FOR CHOLESTEROL LOWERING

 

Level of Risk

 

Target LDL (mmol/L)

 

Total Cholesterol: HDL ratio

 

High
(10yr risk of CAD ³ 20%3 or CV disease or diabetes or CKD or dialysis)

 

< 2.04

 

<4.0

 

Moderate
(10yr risk 10-19%)3

 

< 3.5

 

<5.0

 

Low
(10yr risk £ 10%)3

 

< 4.5

 

<6.0

CAD=coronary artery disease; CV=cardiovascular; CKD=chronic kidney disease
3 level of risk calculated using Framingham risk scores 4optional goal for very high
risk patients (e.g. acute coronary syndrome): LDL < 1.8mmol/L