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Table of Contents
DOSAGE EQUIVALENCE OF HMG CoA
REDUCTASE INHIBITORS
(“STATINS”)
|
Drug |
Approximate Equivalent Dose2 |
|
Lovastatin (Mevacor®) |
40 mg |
|
Pravastatin1 (Pravachol®) |
40 mg |
|
Simvastatin (Zocor®) |
20 mg
(maximum 40 mg/dose) |
|
Atorvastatin1 (Lipitor®) |
10 mg |
|
Fluvastatin (Lescol®) |
80 mg |
|
Rosuvastatin (Crestor®) |
5 mg
|
1 formulary drug;
all statins other than pravastatin will be converted to atorvastatin (see TIP
section)
2 dose equivalence
based on a 25-30% reduction in LDL cholesterol
TARGET GOALS FOR CHOLESTEROL LOWERING
|
Level of
Risk |
Initiate Treatment if: |
Target
LDL (mmol/L) |
|
High
(CAD, PVD,
atherosclerosis, or diabetes
FRS 10yr
risk of CV disease:
³
20% |
Consider
treatment in all patients |
< 2.0
OR
³
50%
¯
baseline LDL |
|
Moderate
FRS 10yr
risk: 10-19% |
LDL > 3.5
mmol/L OR
TC/HDL > 5.0 OR
hs-CRP > 2 mg/L
(test in men > 50 yrs,
women > 60 yrs if LDL < 3.5) |
< 2.0
OR
³
50%
¯
baseline LDL |
|
Low
FRS 10yr
risk: < 10%
|
LDL
³
5.0 mmol/L |
³
50%
¯
baseline LDL |
CAD=coronary artery disease; PVD = peripheral vascular disease;
CV = cardiovascular;
FRS = Framingham Risk Score; TC = Total cholesterol
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