|
Table of Contents
DOSAGE EQUIVALENCE OF HMG CoA REDUCTASE INHIBITORS (“STATINS”)
|
Drug |
Approximate Equivalent Dose3 |
|
Lovastatin (Mevacor®) |
20 mg |
|
Pravastatin (Pravachol®) |
20 mg |
|
Simvastatin1 (Zocor®) |
10 mg
(maximum 40 mg/dose) |
|
Atorvastatin2 (Lipitor®) |
5 mg |
|
Fluvastatin (Lescol®) |
40 mg |
|
Rosuvastatin (Crestor®) |
2.5 mg |
1 formulary drug
2 atorvastatin 80 mg is formulary
3 dose equivalence based on a 25-30% reduction in LDL cholesterol
TARGET GOALS FOR CHOLESTEROL LOWERING
|
Level of
Risk |
Target
LDL (mmol/L) |
Total Cholesterol: HDL ratio |
|
High
(10yr risk of CAD
³
20%3 or CV disease or diabetes or CKD or dialysis) |
< 2.04 |
<4.0 |
|
Moderate
(10yr risk 10-19%)3 |
< 3.5 |
<5.0 |
|
Low
(10yr risk
£
10%)3 |
< 4.5 |
<6.0 |
CAD=coronary artery disease; CV=cardiovascular; CKD=chronic kidney disease
3 level of risk calculated using Framingham risk scores 4optional
goal for very high
risk patients (e.g. acute coronary syndrome): LDL < 1.8mmol/L
|