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Table of Contents
CONVENTIONAL GENTAMICIN & TOBRAMYCIN EMPIRIC DOSING GUIDELINES
TABLE 1: INTIAL DOSE PER INTERVAL
| TOTAL BODY WEIGHT (kg) |
LOADING DOSE (mg)
|
MAINTENANCE DOSE (mg) |
| 40-50 |
120 |
90 |
| 51-60 |
130 |
100 |
| 61-70 |
140 |
110 |
| 71-80 |
150 |
120 |
| 81-90 |
160 |
130 |
| 91-100 |
170 |
140 |
| 101-110 |
180 |
150 |
| 111-120 |
190 |
160 |
TABLE 2: INITIAL DOSING INTERVAL (hours)
Serum Creatinine
(umol/L) |
Age Groups (years) |
| 20-30 |
31-40 |
41-50 |
51-60 |
61-70 |
71-80 |
>80 |
| 40-80 |
8 |
8 |
8 |
8 |
8 |
12 |
12 |
| 81-100 |
8 |
8 |
8 |
8 |
12 |
12 |
12 |
| 101-120 |
8 |
8 |
12 |
12 |
12 |
12 |
18 |
| 121-140 |
8 |
12 |
12 |
12 |
12 |
18 |
18 |
| 141-160 |
12 |
12 |
12 |
18 |
18 |
18 |
18 |
| 161-180 |
12 |
12 |
18 |
18 |
18 |
18 |
24 |
| 181-200 |
12 |
18 |
18 |
18 |
18 |
24 |
24 |
KEY
- Establish patient age, weight and serum creatinine
concentration.
- Using Table 1, identify initial loading dose and maintenance dose per
interval according to
patient weight.
- Using Table 2, identify initial dosing interval according to patient age
and serum creatinine.
- Serum levels should be performed within 72 hours of initial dose.
FOOTNOTES
- Aminoglycosides concentrate in the urine. For UNCOMPLICATED URINARY TRACT
INFECTIONS, reduce the dose per interval by 50%.
- Drug disposition can vary widely, especially in patients with SERIOUS
FLUID
IMBALANCE, BURNS, ASCITES OR PREGNANCY.
- These dosage guidelines are used to estimate an appropriate INITIAL
EMPIRIC DOSAGE
REGIMEN to achieve serum levels in the range of 0.5 -2mg/L (pre) and 5-10mg/L
(post).
These guidelines are NOT A SUBSTITUTION FOR SERUM DRUG LEVEL
MONITORING.
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