Table of Contents

CONVENTIONAL GENTAMICIN & TOBRAMYCIN EMPIRIC DOSING GUIDELINES

TABLE 1:  INTIAL DOSE PER INTERVAL

TOTAL BODY WEIGHT (kg) LOADING DOSE (mg) MAINTENANCE DOSE (mg)
40-50 120 90
51-60 130 100
61-70 140 110
71-80 150 120
81-90 160 130
91-100 170 140
101-110 180 150
111-120 190 160

TABLE 2: INITIAL DOSING INTERVAL (hours)

Serum Creatinine
(umol/L)
Age Groups (years)
20-30 31-40 41-50 51-60 61-70 71-80 >80
40-80 8 8 8 8 8 12 12
81-100 8 8 8 8 12 12 12
101-120 8 8 12 12 12 12 18
121-140 8 12 12 12 12 18 18
141-160 12 12 12 18 18 18 18
161-180 12 12 18 18 18 18 24
181-200 12 18 18 18 18 24 24

KEY

  1. Establish patient age, weight and serum creatinine concentration.
  2. Using Table 1, identify initial loading dose and maintenance dose per interval according to
    patient weight.
  3. Using Table 2, identify initial dosing interval according to patient age and serum creatinine.
  4. Serum levels should be performed within 72 hours of initial dose.

FOOTNOTES

  1. Aminoglycosides concentrate in the urine. For UNCOMPLICATED URINARY TRACT
    INFECTIONS, reduce the dose per interval by 50%.
  2. Drug disposition can vary widely, especially in patients with SERIOUS FLUID
    IMBALANCE, BURNS, ASCITES OR PREGNANCY.
  3. These dosage guidelines are used to estimate an appropriate INITIAL EMPIRIC DOSAGE
    REGIMEN to achieve serum levels in the range of 0.5 -2mg/L (pre) and 5-10mg/L (post).

These guidelines are NOT A SUBSTITUTION FOR SERUM DRUG LEVEL MONITORING.