Table of Contents

 

CO-TRIMOXAZOLE (SULFAMETHOXAZOLE-TRIMETHOPRIM,

BACTRIM, SEPTRA) DOSING

 


Formulation

 

Trimethroprim

 

Sulfmethoxazole

Tablet single-strength (SS)

80 mg

400 mg

Tablet double-strength (DS)

160 mg

800 mg

Suspension

80 mg/10 mL

400 mg/10 mL

Parenteral

80 mg/5 mL

400 mg/5 mL

 

Dosing

 

UTI:  1 DS tablet PO BID or 2 SS tablets PO BID

Skin and Soft Tissue (Community-Associated MRSA): 2 DS tablets PO BID

Gram-negative Sepsis: 2.5 mg/kg trimethoprim PO/IV Q6H

PCP Pneumonia or serious systemic infection: 5 mg/kg trimethoprim PO/IV Q6H

  

Dosing Adjustments in Renal Impairment (ORAL):

 

 

Medication

 

>50mL/min

 

30-50mL/min

 

<30mL/min

 

HD

 

CAPD

Cotrimox-azole1

DS BID

DS BID

DS daily or
SS BID

DS daily or
SS BID

 SS BID

 

1 For invasive infections, higher doses and intervals may be required

 

Dosing Adjustments in Renal Impairment (PARENTERAL):

 

 

Medication

 

>50mL/min

 

30-50mL/min

 

<30mL/min

 

HD

 

CAPD

Cotrimox-azole

(mg/kg TMP)

2.5-5 mg/kg/dose q6h

2.5-5 mg/kg/dose q8h

2.5-5
mg/kg/dose2
q12h

2.5-5mg/kg2 q24h DAD

2.5-5mg/kg2
q24h

 

 2 up to 10 mg/kg/dose for more aggressive therapy