CO-TRIMOXAZOLE (SULFAMETHOXAZOLE-TRIMETHOPRIM,
BACTRIM, SEPTRA) DOSING
|
|
Trimethroprim |
Sulfmethoxazole |
|
Tablet – single-strength (SS) |
80 mg |
400 mg |
|
Tablet – double-strength (DS) |
160 mg |
800 mg |
|
Suspension |
80 mg/10 mL |
400 mg/10 mL |
|
Parenteral |
80 mg/5 mL |
400 mg/5 mL |
Dosing
UTI: 1 DS tablet PO BID or 2 SS tablets PO BID
Skin and Soft Tissue (Community-Associated MRSA): 2 DS tablets PO BID
Gram-negative Sepsis: 2.5 mg/kg trimethoprim PO/IV Q6H
PCP Pneumonia or serious systemic infection: 5 mg/kg trimethoprim PO/IV Q6H
Dosing Adjustments in Renal Impairment (ORAL):
|
Medication |
>50mL/min |
30-50mL/min |
<30mL/min |
HD |
CAPD |
|
Cotrimox-azole1 |
DS BID |
DS BID |
DS daily or |
DS daily or |
SS BID |
1 For invasive infections, higher doses and intervals may be required
Dosing Adjustments in Renal Impairment (PARENTERAL):
|
Medication |
>50mL/min |
30-50mL/min |
<30mL/min |
HD |
CAPD |
|
Cotrimox-azole (mg/kg TMP) |
2.5-5 mg/kg/dose q6h |
2.5-5 mg/kg/dose q8h |
2.5-5 |
2.5-5mg/kg2 q24h DAD |
2.5mg/kg2 |
2 up to 10 mg/kg/dose for more aggressive therapy