Table of Contents

COMPARISON OF BENZODIAZEPINES

Benzodiazepine Onset of Action2 Peak Onset (hrs) Half-life
parent (hrs)

Half-life
metabolite (hrs)

Comparative
Oral Dose
Long Acting
Chlordiazepoxide (Librium®) Int. (po) 2-4(po) 5-30 3-100 10 mg
Diazepam1
(Valium®)
Rapid (po, IV) 1(po) 20-50 3-100 5 mg
Flurazepam
(Dalmane®)
Rapid 0.5-2 inactive 47-100 30 mg
Intermediate  Acting
Alprazolam1
(Xanax®)
Int. 0.7-1.6 6-20 - 0.5mg
Clonazepam1
(Rivotril®)
Int. 1-4 18-39 - 0.25mg
Lorazepam1
(Ativan®)

Int. (po),
Rapid (sl, IV)

1-1.5 (po) 10-20 - 1mg
Oxazepam1
(Serax®)
Slow 2-3 3-21 - 15mg
 Temazepam1
(Restoril®)
Slow  0.75-1.5 10-20 -  30mg
Short Acting
Midazolam1
(Versed®)
 Most  Rapid IV 0.5-1 (IV ) 1-4 - -
Triazolam
(Halcion®)
Int. 0.75-2 1.6-5.5 - 0.5mg

1 formulary drug
2 Rapid onset = within 15 minutes, Intermediate = 15-30 minutes, Slow = 30-60 minutes