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Table of Contents
AMINOGLYCOSIDE AND VANCOMYCIN SERUM LEVEL
MONITORING
(CONVENTIONAL DOSING)
|
DRUG |
INFUSION TIME1 |
DRAW TIMES1 |
NORMAL THERAPEUTIC
RANGE (mg/L) |
|
GENTAMICIN & TOBRAMYCIN |
30
min |
PRE:
within 30 minutes prior to dose
|
PRE:
< 2.0 mg/L
|
|
POST:
greater than or equal to 30 minutes
after end of infusion
|
POST:
4-10 mg/L2
|
|
AMIKACIN |
30
min |
as
for gentamicin and tobramycin |
PRE:
< 10 mg/L
|
|
POST:
20-30 mg/L2 |
|
VANCOMYCIN |
<
1250 mg: 60 min
>1250mg: 90 min |
PRE:
within 30 minutes prior to dose
|
PRE
5-20 mg/L2
|
|
POST
greater than or equal to 3 hours
after end of infusion |
POST
15-30 mg/L2,3
|
1
Specify ACTUAL time infusion started, finished and serum level draw times on the
drug level requisition form.
Inaccurate documentation of infusion and draw times will lead to erroneous
interpretation of serum levels.
2
Dependent on infection and patient factors.
3
Calculated CPMAX of 20-40mg/L desired; post-vancomycin levels should
not be routinely ordered.
Please refer to Vancomycin Empiric Dosing Guidelines: Therapeutic Drug
Monitoring section.
If the guidelines are used, steady-state conditions will usually
be reached after 3-4 doses have been administered.
For this reason, blood sampling on or after the third dose following a change in
therapy is recommended.
In serious infections, earlier blood sampling may be desired.
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