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(C) Vancouver
General Hospital.
This monograph may not be reproduced without permission.
For further information, please contact a Pharmacist. |
NAME OF DRUG
clindamycin phosphate
CLASSIFICATION
Antibiotic
ALTERNATE NAME
DALACIN C
INDICATIONS
- treatment of serious infections caused by susceptible strains of anaerobic
and gram positive micro-organisms when oral therapy is not feasible
RECONSTITUTION AND STABILITY
- stable at room temperature
COMPATIBILITY
- compatible with NS, D5W, D5S
- compatible via Y-site acyclovir, amikacin, amphotericin B,
ampicillin, calcium gluconate,
cefamandole, cefazolin, cefotaxime, ceftazidime, ceftizoxime, ceftriaxone, cefuroxime, cyclosporine,
gentamicin, heparin, hydrocortisone, hydromorphone, levofloxacin, magnesium sulphate, meperidine, methylprednisolone,
metoclopramide, metronidazole, morphine, MVI, ondansetron, penicillin G, piperacillin-tazobactam,
potassium chloride, potassium phosphate, sodium bicarbonate, tobramycin
- incompatible with calcium gluconate
- do not mix with other drugs in the same container
ROUTES OF ADMINISTRATION
- IM
- injections greater than 600 mg should be given into separate sites
- IV intermittent
- administer over 20-40 minutes (maximum rate 30
mg/minute and maximum dilution 12mg/mL) as follows:
| Dose |
Diluent |
Infusion Time |
| 300-600mg |
50mL |
20 minutes |
| 900mg |
100mL |
30 minutes |
| 1200mg |
100mL |
40 minutes |
VH & HSC ADMINISTRATION POLICY
A - Not to be administered by the direct IV route.
DOSAGE
IM/IV:
- Moderate infections: 300-600 mg every 8 hours
- Severe infections: 600-900 mg every 8 hours
NOTE: Single IM doses greater than 600 mg not recommended
MAXIMUM DOSE: 4.8 g/day (life-threatening infections)
Therapeutic Interchange Policy: unless specifically stated otherwise, all orders for
clindamycin will be changed to a q8h dosing interval if orderd £ q6h (effective May 1988)
POTENTIAL HAZARDS OF PARENTERAL ADMINISTRATION
thrombophlebitis, erythema, swelling and pain at IV injection site
pain, induration, and sterile abscess at IM injection site
cardiac arrest may result if administered undiluted
IMPORTANT IMPLICATIONS
some cases of severe and persistent diarrhea have been reported (pseudomembraneous
colitis association)
reduce dosage in severely impaired liver function
does not cross blood-brain barrier even in the presence of inflamed meninges
Rev. Feb 2006