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(C) Vancouver
General Hospital.
This monograph may not be reproduced without permission.
For further information, please contact a Pharmacist. |
NAME OF DRUG
chloroprocaine hydrochloride
CLASSIFICATION
Local anesthetic-ester type
ALTERNATE NAME
NESACAINE CE
INDICATIONS
- local anesthesia by infiltration and regional nerve block, including caudal and
epidural blocks
RECONSTITUTION AND STABILITY
- discard unused portion of vial
- protect from direct sunlight - may become discoloured (do not administer discoloured
solutions)
- crystals which may form on exposure to low temperatures redissolve by warming; do not
administer if crystals do not redissolve
COMPATIBILITY
- incompatible with other drugs in a syringe
ROUTES OF ADMINISTRATION
- Caudal and Epidural block
VH & HSC ADMINISTRATION POLICY
C - Must be administered by the physician by all routes.
DOSAGE
- individualized using a 2% or 3% solution
Caudal Anesthesia:
- 15-25 mL repeated at 40-60 minute intervals
Epidural:
- Cervical or thoracic region: 1.5-2 mL for each segment
- Lumbar and sacral region: 2.0-2.5 mL per segment
- Usual total volume is 15-25 mL
- Repeated doses 2-6 mL less than original dose at 40-50 minute intervals
Maximum single dose: 800 mg
POTENTIAL HAZARDS OF PARENTERAL ADMINISTRATION
- Adverse effects from high plasma levels:
- CNS - stimulation and depression including convulsions, unconsciousness, respiratory
arrest
- Cardiovascular - hypotension, bradycardia, cardiac arrest
IMPORTANT IMPLICATIONS
- contraindicated in patients hypersensitive to drugs of PABA ester group
- avoid intravascular injection
- resuscitative equipment and drugs for treatment of adverse reactions must be readily
available
Rev. October 1985