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(C) Vancouver
General Hospital.
This monograph may not be reproduced without permission.
For further information, please contact a Pharmacist. |
NAME OF DRUG
cefuroxime sodium
CLASSIFICATION
Cephalosporin antibiotic
ALTERNATE NAME
ZINACEF
INDICATIONS
- prevention or treatment of systemic infections caused by susceptible strains of
micro-organisms
RECONSTITUTION AND STABILITY
- powder stable at room temperature
- IM
- reconstitute 750 mg vial with 3.0 mL sterile water for injection to yield a 220
mg/mL solution
- IV
- reconstitute 750 mg vial with 8.0 mL sterile water for injection to yield a 90
mg/mL solution
- reconstitute 1500 mg vial with 16 mL sterile water for injection to yield a 90 mg/mL
solution
- reconstituted solutions should be stored in the refrigerator; discard after 24 hours
COMPATIBILITY
- compatible with most commonly used IV solutions
- compatible via Y-site with acyclovir, ceftazidime, clindamycin, cyclosporine,
furosemide, gentamicin, heparin, meperidine, metronidazole, morphine,
multivitamins, ondansetron, potassium chloride
- do not mix with other drugs in the same container
ROUTES OF ADMINISTRATION
- IM - into a large muscle mass
- IV direct - administer over 3-5 minutes
- IV intermittent - further dilute in 50-100 mL of a compatible IV solution and infuse
over 15-30 minutes
VH & HSC ADMINISTRATION POLICY
E - Direct IV route can be administered by nurses on general nursing units provided a
venous access has been established and according to policies and recommendations stated in
this manual.
DOSAGE
Adults: 750 - 1500 mg IM/IV every 8-12 hours depending on the severity of the infection
Children: 75-150 mg/kg/24 hours IV/IM divided every 8 hours
Dosage adjustments are required in renal insufficiency
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Creatinine Clearance |
Dosage |
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30-50 mL/min |
0.75-1.5 g q8-12h |
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< 30 mL/min |
0.75-1.5 g q12h |
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Hemodialysis |
0.75-1.5 g q24h DAD* |
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CAPD |
0.75-1.5 g q24h |
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DAD* = give dose after dialysis (on hemodialysis
days) |
POTENTIAL HAZARDS OF PARENTERAL ADMINISTRATION
- thrombophlebitis, stiffness and or an inflammatory reaction at the injection site
- pain at IM injection site
- hypersensitivity reactions
IMPORTANT IMPLICATIONS
- contraindicated in patients with a history of allergic reactions to cephalosporins
- use with caution in patients with a history of allergic reactions to penicillins
- produces a false positive urine glucose with clinitest; use Clinistix or Tes-tape if
urinary glucose is being monitored
Rev. May 2008