|
|
|
(C) Vancouver
General Hospital.
This monograph may not be reproduced without permission.
For further information, please contact a Pharmacist. |
NAME OF DRUG
cefazolin sodium
CLASSIFICATION
Cephalosporin antibiotic
ALTERNATE NAME
ANCEF, KEFZOL
INDICATIONS
- treatment of systemic infections caused by susceptible strains of micro-organisms
RECONSTITUTION AND STABILITY
- powder is stable at room temperature, protect powder from light
- reconstitute with sterile water for injection or NS
- add 2 mL diluent to 500 mg vial to provide a concentration of 225
mg/mL
- add 2.5 mL diluent to 1,000 mg vial to provide a concentration of 330
mg/mL
- reconstituted solutions should not be stored longer than 24 hours in refrigerator
COMPATIBILITY
- compatible with most commonly used IV solutions
- compatible via Y-site with acyclovir, amikacin, calcium gluconate, ceftazidime,
clindamycin, cyclosporine, fluconazole, heparin, hydromorphone, insulin regular, magnesium sulphate, meperidine,
metronidazole, morphine, MVI, ondansetron, pantoprazole, potassium chloride, potassium phosphate,
ranitidine
- incompatible with most other drugs
ROUTES OF ADMINISTRATION
- IM - deeply into muscle
- IV direct - further dilute reconstituted solution with a minimum of 10 mL sterile water
for injection or NS and administer over 3-5 minutes
- IV intermittent - dilute reconstituted solution in 50-100 mL of IV solution and
administer over 15-30 minutes
- give dose post dialysis in hemodialysis
patients
VH & HSC ADMINISTRATION POLICY
E - Direct IV route can be administered by nurses on general nursing units provided a
venous access has been established, and according to policies and recommendations stated
in this manual.
DOSAGE
Adults: 250-2,000 mg every 8 hours
Children: 25-100 mg/kg/day given in equally divided doses every 8 hours
NOTE: Dosage adjustments are necessary in renal dysfunction
|
Creatinine Clearance |
Dosage |
|
30-50 mL/min |
1-2 g q12h |
|
< 30 mL/min |
1-2 g q12-24h |
|
Hemodialysis |
1-2 g DAD* or 0.5-1 g q24h DAD* |
|
CAPD |
500 mg q12h |
|
*DAD = give dose after dialysis (on hemodialysis
days) |
Therapeutic interchange program: unless specifically stated otherwise, all orders for
cefazolin will be changed to a q8h dosing interval if ordered £ q6h (effective July 1986)
POTENTIAL HAZARDS OF PARENTERAL ADMINISTRATION
- pain at IM injection site
- thrombophlebitis after IV use
- allergic reactions
IMPORTANT IMPLICATIONS
contraindicated in patients hypersensitive to cephalosporins
use with caution in patients with a history of penicillin allergy
can cause false positive Coombs test in uremic patients
1 g cefazolin yields 2 mmol (2 mEq, 48.3 mg) sodium
use Clinistix or Tes-tape if urinary glucose is being monitored - causes false
positive urine glucose with clinitest
Rev. May 2008